Company Overview
Cyberkinetics Neurotechnology Systems, Inc. (Cyberkinetics, OTCBB:CYKN) is commercializing products based on two proprietary, cutting-edge neurotechnology platforms: neural stimulation to regenerate neural tissue and neural sensing and decoding. Both of these platforms are being developed to restore function for those with a wide range of nervous system injuries, diseases and conditions, including spinal cord injury, motor neuron diseases and brain trauma. These platforms combine advances in neuroscience, computer science and engineering that are based on decades of combined fundamental scientific research and early clinical trials.
Regenerate Neural Tissue and Restore Function
 The AndaraTM Oscillating Field Stimulator (OFS) technology platform is based upon the application of oscillating, low-voltage, direct current of electricity to the areas above and below a spinal cord injury. Designed to stimulate the neural fibers surrounding the spinal cord to grow across the area of injury, The AndaraTM OFS technology is designed to restore sensory and motor function and is based on more than two decades of preclinical research at world-leading universities.
Diseases and disorders of the central nervous system account for more hospitalizations, more long-term care and more chronic suffering than nearly all other disorders combined. They also represent the largest and fastest growing area of unsatisfied medical need, with more than 1.5 billion people worldwide, including over 100 million people in the United States alone. Central nervous system conditions generate more in total direct healthcare-related and indirect costs, such as lost income, than any other therapeutic area -- an estimated $1.0 trillion annually worldwide, including over $350 billion annually in the United States.
Only about the size of your little finger, the AndaraTM OFS Device is implanted into muscle tissue beside the spinal column within 18 days following injury and electrical leads are attached onto the bone above and below the area of injury. The Andara OFSTM Device is an investigational device that has demonstrated in Phase I clinical trials that it can regenerate neural fibers and improve or restore tactile sensation and movement in those with quadriplegia and tetraplegia due to spinal cord injury.
The AndaraTM OFS PLUS System is being designed to be used in conjunction with a growth factor and is intended to be used to treat chronic, or old, injuries. The Andara OFS PLUS System is currently being tested in a preclinical study.
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Sense and Decode Neural Activity
 Cyberkinetics' award-winning BrainGate and NeuroPortTM Systems are based upon the Company's innovative 100-electrode array that directly senses -- in real time -- the electrical signals transmitted between individual neural cells in the brain and computer software designed to decode the meaning of those electrical signals.
The BrainGate Neural Interface System (BrainGate System) is designed to turn thought into action by collecting and analyzing neural signals from the motor cortex, which is the part of the brain that controls muscle movement. Our initial focus is to improve quality of life for the over 400,000 people with sever motor impairments from diseases and disorders such as spinal cord injury (SCI), brain-stem trauma, amyotrophic lateral sclerosis (ALS), muscular dystrophy (MD) and stroke. An investigational device, the BrainGate System is currently being tested in pilot clinical trials for those with spinal cord injury, stroke and muscular dystrophy aimed at restoring limb movement; and a trial for those with ALS and other motor neuron diseases aimed at restoring communication. Cyberkinetics' BrainGate System is designed to allow physically disabled people to use their thoughts to quickly and reliably control a wide range of devices including computers, environmental controls, robotics and medical devices.
Cyberkinetics research equipment, which is based on the same fundamental neural sensing and decoding platform, is currently sold to leading neuroscientists for use in laboratories around the world. Cyberkinetics' research systems include a stable sensor for detecting brain cell activity coupled to robust signal processors to enable the analysis and decoding of these signals. The system is capable of both short and long-term recordings directly from the brain.
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